Physically, Peter is in very good health, despite being fat, alcoholic, and accident-prone. He successfully played pro football for the New England Patriots, can run down and beat up a mugger, and can sustain a lengthy and destructive fistfight with his nemesis, the giant chicken. He also ran surprisingly well in one episode while trying to catch Max Weinstein. Also, when Death was about to take him away, he told Death he ran two weeks of track when he was younger, and he ran away.
In the episode
Death Is a Bitch Lois detects a lump in Peter's breast, leading them to believe that Peter had breast cancer. It was later revealed to be a fatty
corpuscle (which he at first confused with the late
Fatty Arbuckle).