2.5" overhang is palin stupid, both for on road and offroad.
You want the wheel/tire combo to be more or less in the stock position so that the wheel can articluate and not foul the fenders etc.
You also want to maintain the turning ratio as close as possible to stock or you will be doing three point turns on the trail - not recommended
Wheel/tire combos?
Run whatever tire you want on whatever wheel.
I'm a big Super Swamper fan but I also like MT/Rs.
-C